DNA methylation in peripheral blood and risk of gastric cancer: A prospective nested case-control study

JA Chamberlain; PA Dugué; JK Bassett; RL Milne; JE Joo; EM Wong; MT Brinkman; GW Stuart; A Boussioutas; MC Southey; GG Giles; H Mitchell; DR English; AM Hodge

Journal article

DNA methylation in peripheral blood and risk of gastric cancer: A prospective nested case-control study

JA Chamberlain, PA Dugué, JK Bassett, RL Milne, JE Joo, EM Wong, MT Brinkman, GW Stuart, A Boussioutas, MC Southey, GG Giles, H Mitchell, DR English, AM Hodge

Cancer Prevention Research | AMER ASSOC CANCER RESEARCH | Published : 2021

DOI: 10.1158/1940-6207.CAPR-20-0003

Abstract

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case-control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA was prepared from blood samples collected a median of 12 years before diagnosis for cases (N = 168). Controls (N = 163) were matched to cases on sex, year of birth, country of birth, and blood sample type using incidence density sampling. Genome-wide DNA methylation was measured using the Infinium Human Methylation450K Beadchip. Global measures of DNA methylation were defined as the median methylation M value, calculated for each of 13CpGsubsets representin..

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University of Melbourne Researchers

Pierre-Antoine Dugue Author

Roger Milne Author

Eric Joo Author

Geoff Stuart Author

Related Projects (4)

Epidemiology of chronic disease, health interventions and DNA studies

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

MOLECULAR BIOLOGY OF GASTRIC CANCER

We will investigate whether there are particular patterns of DNA methylation in people who develop gastric cancer. This could provide a mean..

THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

Grants

Awarded by VicHealth

Funding Acknowledgements

The MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCSwas further augmented by Australian National Health and Medical Research Council grants 209057, 396414, 1074383, and 1087683 and by infrastructure provided by Cancer Council Victoria. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.